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The Neurolog modular system is widely accepted throughout the world by scientists who demand high quality, dependability and innovation in their research instrumentation. One of the major advantages of this system is its modularity: only those functions (modules) actually required are purchased. Individual modules can be added to the system at any time, as the scope of its application changes.
There is a choice of nearly 50 modules for use by clinicians as well as electrophysiologists. Applications covered by the Neurolog system include: intracellular and extracellular recording, filtering, spike discrimination, pressure monitoring, signal averaging, stimulation, timing and isolated human physiological recording. For an impression of how a group of modules with various functions can be combined in one Neurolog 19" (rack-mountable) case, see the graphic at the top of this section, or its high-res representation.

The base of the Neurolog system is the NL 900C case with built-in power supply. This 19" case is rack-mountable, and can contain (and power) up to 13 modules. Modules slide easily in place from the front of the case, and lock in place by a built-in retention system. Neighbouring modules are automatically interconnected through edge connectors at the back of the module's circuit boards. The front panel controls are therefore not obscured by connecting cables. However, in some cases front connections cannot be avoided, for example when the output of one module serves as input for two or more other modules. In such cases, front panel connections are made by miniature, screened coax cables with microminiature coaxial connectors. A variety of high-quality cables, plugs, adaptors and T-connectors assembled in Canada are available directly from IBIS Instrumentation.
 
Below is a list of the various Neurolog parts and modules available. For further information, please contact us.
 

 

Modules

NL900C Case System and Power Supply Unit   NL04 Tungsten Micro-Electrode Holder - see NL100AK NL50 Blank module for Prototypes   NL100A Pre-Amplifier First Stage for NL103 - see NL100AK NL100AK Pre-Amplifier, First Stage   NL101 Electrode Chambers NL102G DC Pre-Amplifier   NL104A AC Pre-Amplifier NL106 AC/DC Amplifier   NL107 Recorder Amplifier NL108A Pressure Amplifier   NL108T1 Isolated Pressure Transducer  NL108T2 Disposable Pressure Transducer   NL108T3 Isolated Pressure Transducer (type 840) NL108D3 Sterile Domes For NL108T3   NL118 Octal Band-Pass Filter Amplifier NL120 Audio Amplifier   NL125/126 Filter (Low-cut, High-cut and 50Hz/60Hz Notch) NL134 4-Channel Low-Pass Filter   NL135/136 4-Channel Low-Pass Filter and 50Hz/60Hz Notch) NL201 Spike Trigger   NL202 AC Signal Delay NL253/256 Instantaneous Ratemeters (ppm/pps)   NL301 Pulse Generator (replaces NL300) NL304 Period Generator (replaces NL303)   NL310 Ramp Generator NL401 Digital Width   NL403 Delay Width NL410 Calibrator Module   NL501 'AND/OR' Logic Gates NL505 Flip-Flop   NL506 Analogue Switch NL510 Pulse Buffer   NL515 Interface Module NL520 Converter   NL530 Conditioner (4-channel) NL601 Pulse Integrator   NL603 Counter NL606 Latched Counter   NL700 LOG. Display NL701 LIN. Display   NL702 Ratemeter NL703 EMG Integrator   NL705 RMS EMG Integrator NL730 Pulse Shift   NL741 Analogue Delay NL750 Signal Averager   NL751 Remote for NL750 NL752 Pulse Interval Histogram Module for NL750   NL753 Artefact Rejection NL755 Serial I/O for NL750 inc. PC Software   NL800 Stimulus Isolator - Constant Current NL820 Isolation Amplifier (4-channel)   NL822 2-Channel Remote AC Pre-Amplifier NL824 4-Channel Remote DC Pre-Amplifier   NL834 4-Channel Remote DC Pre-Amplifier NL832 2-Channel Remote DC Pre-Amplifier       NL850A Isolated Pre-Amplifier (Single Channel)

 
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The D330 MultiStim System is a modular and highly versatile multi-channel stimulator designed to be used by biomedical scientists who wish to accurately stimulate a number of low impedance tissue preparations with different stimulating voltages or currents. The output channels are fully protected and galvanically isolated from ground so that a single earthing point can be chosen and loops avoided.

The system provides a choice of modules for either constant voltage stimulation (up to 100V at 200mA or 1A) or constant current stimulation (up to 500mA from a 100V source). The D335 - Meter can be fitted into the system to allow precise voltage or current monitoring.

A selection of timing modules are available to generate pulses, variable in frequency and width, which can be controlled as bursts using a gating waveform, variable in repetition rate and duration or pulse count. For ease of use, most modules have an error indicator to warn of incompatible settings or an overload condition. Sockets are fitted to allow full external control and synchronisation if required.

The D330 MultiStim System rack/case is available in two sizes. There is a 19" rack-mountable unit that can house up to ten stimulation channels (see photo above or one with a higher resolution).
A 'half-width' bench-top unit capable of taking up to four stimulation channels - along with the Pulse Train Generator and Gating modules- is also available.

The D345 PowerStim is an extension of the D330 MultiStim System range, and provides the controlled high power stimuli from a low impedance source needed for Field Stimulation of preparations in extra low impedance baths. It provides up to 80V at 2.5A from each of its four overload protected channels and these outputs can be externally combined to give two 5A channels or a single 10A.

The modularity of the system allows a system to be extended or split between smaller units for two sites.

 
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Many experiments in electrophysiology use a brief pulse of current as a stimulus to excite nerve or muscle fibres. The voltage required to send this current through tissues can vary over a wide range. In addition, in order to minimise artefacts in the experimental results, it is desirable that the source of this e.m.f. should be isolated both from ground and from the timing generator used to release the stimulus. 

The DS2A can be supplied as a constant voltage or as a constant current source, to be specified at the time of ordering. Existing constant voltage models can be retrofitted with the constant current option by Digitimer England.

The DS2A fulfills these requirements by using self contained batteries as the source of power and optical coupling is employed to isolate the stimulator from the trigger source. 
A Digitimer Programmer can be used to set the precise time of application of the stimulus in the experimental cycle. The duration of the stimulator output is adjustable over the range of 20 microseconds to two seconds by controls on the stimulators. 
A switch selects maximum outputs of 7 Volts or 97 Volts, both ranges continuously adjustable by means of a multi-turn output control. The polarity of the output can be reversed by a front panel switch.
Current is drawn from the batteries only when delivering an output pulse thus minimising the drain on them. The maximum current drain is 30mA plus the load current. 
The output impedance is less than 1300 ohms for any position of the output controls and an automatic overload detector protects the instrument against short circuits. 
The instrument is made of insulating material and may be mounted on a metal mounting frame without connecting the internal circuits of the instrument to ground. A single shot button is provided. This operates at all times irrespective of other trigger inputs. 

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	The Digitimer High Voltage Stimulator model DS7A provides constant current high voltage pulses of brief duration for percutaneous stimulation during investigation of the electrical activity of nerve and muscle tissue. The output current is continuously variable over the range 0 to 100 milli-Amps, from a source voltage continuously variable from less than 100 Volts to 400 Volts, to meet the requirements of human pathological cases. For higher voltages the Digitimer Stimulator Model D185 is suggested.  Short pulse durations have been made available in the DS7A to minimise any discomfort to the subject. The pulse width range can be varied from 50 micro-seconds to 2 milli-seconds in six steps. A specially designed isolated output stage maintains a square (current) pulse shape while minimising stimulus artefacts.
The DS7AH option, allowing currents upto 1A with a maximum pulse duration limit of 200µs, is also available. This model is offered to overcome the difficulties of stimulating deep peripheral nerves, or large muscles such as the quadriceps with large area electrodes.
	The instrument is mounted in a non-conductive free standing case and is mains powered. The stimulator requires a TTL trigger pulse input and triggers on the positive edge (negative edge can be internally selected). Alternatively a foot switch may be connected to a socket on the rear panel or the front panel push button pressed. A TTL compatible Trigger output is provided at a BNC socket at the rear panel.

 

This small free-standing instrument has been designed for control of normal repetitive stimulation as well as for defining the Effective Refractory Period using a second, delayed pulse. This unit is especially useful for use with the Digitimer DS2A and DS7A Isolated Stimulators which have their own Pulse Width controls. 

The unit features control of Rate/Frequency over 3 full decades and selection of single or twin pulses with 3 decade control of inter-pulse Delay. A single shot button is fitted to supply pulses on demand when the oscillator is off or in addition to the repetitive stimuli when the oscillator is on. 

A 'SYNC' output socket is available for triggering recording devices. The 'OUT' output can be selected as either the non-delayed pulse, the delayed pulse or both (twin) pulses. 

 
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		The D130 Spike Processor provides, in one unit, many of the facilities required by electrophysiologists who wish to ascertain a correlation between an external stimulus and the mean rate of firing of a nerve cell.  The function of the Spike Processor is that of a Window discriminator with integral Audio Monitoring and counting of multiple unit activity.
The D130 Spike Processor, with shown in the inset three available Output Signals. Monitor (upper trace), Window (middle trace) and Recorder (lower trace).
The two discrimination levels are independently variable over the range of -10V to +10V using ten turn potentiometers and turns counting dials directly calibrated in volts.  The Monitor Output sockets display on an oscilloscope the inout signal with the discrimination levels superimposed thereby enabling accurate height discrimination to be achieved.A four decade counter follows the output of the discrimination circuits with an internal timer controlling the resetting of the counter that provides a display of the number of the spikes counted during the previous timing period. This number is displayed digitally on the front panel, as an analog ramp at the recorder sockets and is also available in 3 decade BCD at the rear output socket.  The analog output has five ranges giving a full scale output for counts from 25 to 500. For larger counts a decade divider can be switched in to extend the capacity to 5000.  The equipment can operate in several modes to suit the application:  1.'STORE' The number of spikes counted during one period is stored and displayed during the following period - this is continuously updated. A 'Pulses per Timing period against time' histogram appears at the recorder output sockets.  2.'DIRECT' The spike count can be followed directly from either the digital display or the 'ramp' at the recorder output sockets.  3.'SINGLE' Following a manual or electrical reset action, the counter operates for one timing period only then stops, displaying the count obtained, until a further reset.  4.'GATED' This provides for complete external control of the counter. The leading edge of an external pulse resets the counter to zero and counting continues as long as the external input active (positive or negative logic) counting stops when the input goes inactive and the count obtained is displayed until the input goes active again, when the cycle repeats.

D130-SW PC Software

The Digitimer D130 Spike Processor provides, in one unit, many facilities required by electrophysiologists who wish to ascertain a correlation between an external stimulus and the mean rate of firing of a nerve cell. 

The D130-SW PC Software has been designed to remove the repetitive task of manually logging count frequency from the D130 Spike Processor. 

Using the supplied digital input card and inter-connecting lead, the software monitors the BCD outputs from the D130capturing the displayed count at the end of each count period. This count is stored in a list which at the end of the expirement can, optionally, be stored in a disk file as ASCII. The data file can then be imported into third party analysis tools such as a spreadsheet. 

The disk files created can contain the count number and the latency of the count allowing extended analysis to be performed by third party software. 

• Count Range : 000 - 999 
• Min. Count Period : 250ms 
• Items in List : Up to 30,000 
• Event Marking : Up to 20 User defineable events

REQUIREMENTS

• PC (minimum), 20MHz Intel 80386 with 640KB of memory running Microsoft Windows 3.1 or later; 1/2 Length EISA card slot free.

 
 
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